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Methods to improve the uterine lining before embryo transfer
The uterine lining is one of the most important factors that determine the success of embryo transfer in IVF programs, as it must be of a suitable thickness and have tissues rich in blood vessels for the embryo to attach and pregnancy to occur.
A thin or weak uterine lining can lead to implantation failure, even with high-quality embryos. Therefore, the uterine lining must be prepared to ensure the highest chances of a successful pregnancy, and this may be achieved through medications or specific techniques.
And in the following article we are going to talk briefly about novel technologies that are used to improve uterine lining and increase success rates such as growth factors and PRP.
What is the definition of growth factors?
They are natural proteins that stimulate cells to repair and generate.
What is the role of growth factors in human body?
** development
** wound healing
** maintenance of tissue
Do abnormalities in the level or signaling of growth factors affect fertility?
Yes, in both men and women
What is the role of growth factors in fertility?
** regulate ovarian processes (egg maturation and survival)
** regulate processes in testis (sperm maturation and motility)
** regulate processes in endometrium (receptivity and growth)
** plays an important role in early embryo development
Does administration of growth factors enhance endometrial function?
Yes, as altered levels of growth factors lead to implantation failure and recurrent miscarriage.
What are the uses of growth factors in fertility domains (ICSI/IVF)?
** in patients with poor ovarian response to enhance follicle growth and maturation
** in patients with recurrent failure to enhance endometrial proliferation, receptivity and embryo implantation
** in patients with poor sperm quality to enhance sperm development and motility
What is PRP therapy?
Platelet-rich plasma therapy, a concentrate of platelets derived from patients own blood through centrifugation, injected into the ovaries or uterus and contains many growth factors.
Are there synthetic growth factors to use in infertility?
Yes, there are many preparations that are produced and are showing satisfactory results.
Dr Najeeb Layyous F.R.C.O.G
Consultant Obstetrician, Gynecologist and Infertility Specialist
